ÇãÀ¯¹Ì(Heo Yu-Mi) - Kyung Hee University School of Medicine Department of Physiology
½Å¸»¼ø(Shin Mal-Soon) - Kyung Hee University School of Medicine Department of Physiology
ÀÌÀç¹Î(Lee Jae-Min) - Kyung Hee University School of Medicine Department of Physiology
±èâÁÖ(Kim Chang-Ju) - Kyung Hee University School of Medicine Department of Physiology
¹é»óºó(Baek Sang-Bin) - University of Ulsan College of Medicine Gangneung Asan Hospital Department of Psychiatry
±è°èȯ(Kim Khae-Hawn) - Gachon University Gil Medical Center Department of Urology
¹é¼º¼ö(Baek Seung-Soo) - Sangmyung University College of Natural Science Department of Sport & Health Science
Abstract
Purpose: Scopolamine is a nonselective muscarinic cholinergic receptor antagonist, which induces impairment of learning ability and memory function. Exercise is known to ameliorate brain disturbance induced by brain injuries. In the present study, we investigated the effect of treadmill exercise on short-term memory in relation to acetylcholinesterase (AChE) expression in the hippocampus, using a scopolamine-induced amnesia model in mice.
Methods: To induce amnesia, 1 mg/kg scopolamine hydrobromide was administered intraperitoneally once per day for 14 days. A step-down avoidance test for short-term memory was conducted. AChE histochemistry, immunohistochemistry for collagen IV, and doublecortin were performed.
Results: Short-term memory deteriorated in the mice with scopolamine-induced amnesia, concomitant with enhanced AChE expression and suppression of angiogenesis in the hippocampus. Critically, treadmill exercise ameliorated short-term memory impairment, suppressed AChE expression, and enhanced angiogenesis in the mice with scopolamine-induced amnesia.
Conclusions: Overexpression of AChE is implicated in both brain and renal disease. The findings of our study indicate that treadmill exercise may be of therapeutic value in neurodegenerative and renal diseases by suppressing the effects of AChE expression.
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Amnesia, Exercise test, Short-term memory, Acetylcholinesterase
KMID :
1240020140180010016
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